Composition: Each uncoated Tablet contains
Praziquantel USP 50 mg
Pyrantel Embonate BP 144 mg
Febantel 150 mg
Dosage: 1 Tablet per 10 kg body weight.
Caution: Do not exceeding recommended dose when treating pregnant bitches. Do not use simultaneously with piperazine compounds. Tapeworm infestation is certain to re-occur unless control of intermediate host such as fleas, mites etc., is undertaken.
Praziquantel is prescribed by a veterinarian to treat tapeworms in pets. Tapeworms are spread by ingesting a flea or louse that has in turn ingested a tapeworm egg. A flea preventative may also be prescribed in conjunction with administration of Praziquantel to prevent any future tapeworm infections.
Pyrantel embonate :
Pyrantel, an anthelmintic of the tetrahydropyrimidine group of compounds, acts in a similar way to levamisol, by inducing a depolarising neuromuscular blockade. Pyrantel, being a cholinergic agonist, acts as an excitatory neurotransmitter at the nicotinergic receptor causing spastic pralysis of the parasite. The embonate salt of pyrantel is poorly soluble in water, which offers the advantage of reduced absorption from the gut, allowing the drug to express its high nematocidal efficacy directly within the digestive tract.
The mechanism of action of febantel is primarily based on interference with the carbohydrate metabolism of the worm. The suppression of mitochondrial reactions (inhibition of fumarate reductase) and interferencewith glucose transport act not only on all developmental stages of the helminths but also on the eggs containing the larvae. Benzimidazoles bind to the structural protein tubulin, thereby preventing its polymerization to microtubules which provide the transport system for the absorbing cells. The consequence of blocking this transport activity is incomplete absorption and digestion of nutrient particles and cellular autolysis through activation of lysosomal enzymes.
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